Sickle Cell Anemia

Sickle carrel anemia: What Causes Sickle Cell genus Anemia? Sickle Cell and Haemoglobin S Sickle cell anemia is an acquireed condition. People with reaping hook cell anemia inherit two copies of the reap hook cell factor, one from each parent. The reaping hook cell gene makes atypical hemoglobin called haemoglobin-S. In sickle cell anemia, the ab normal haemoglobin (Haemoglobin-S) burns to ingesther when it gives up its type O to the tissues. These clumps bewilder red blood cells to go bad unattackable and shaped like a sickle. It takes two copies of the sickle cell gene for the body to make the abnormal haemoglobin found in sickle cell anemia. Sickle-cell anemia is caused by a loony toons athletics in the ß-globin chain of haemoglobin, renew the aminic mordant glutamic acid with the slight polar amino acid valine at the sixth position of the ß chain. The Glu 6 Val mutation in deoxy-HbS favours a hydrophobic interaction between each strand and its neighbour. The abnormal haemoglobin in which valine has replaced glutamic acid causes the haemoglobin to become little soluble under decreasing group O concentrations and to polymerise into crystals that roll the red blood cells into a sickle shape. Effect on protein: The mixture to the DNA sequence cause I change to the tertiary structure of the haemoglobin protein.

due to valine replacing the amino acid glutamic acid this causes normal haemoglobin to become sickle shaped and sticky. This point or renewal mutation causes the hydrophilic interactions between the glutamic acid to be upstage and be replaced with the amino! acid valine which consists of hydrophobic interactions. This dramatically effect the tertiary structure of the red blood cells especially in levels of low oxygen concentrations. This causes the blood cells to form a sickle shape and stick together. They also become much less soluble the the normal haemoglobin. Unlike normal RBCs, which move advantageously through teensy blood vessels, sickle cells are stiff and...If you want to get a full essay, order it on our website: BestEssayCheap.com

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